definition:

The organic acid compound formed by the reaction of calcium carbonate, citric acid and malic acid in a certain proportion has the advantages of high solubility, high biological absorption and utilization, reduced iron absorption hindrance, good flavor, safety and non-toxicity.

Composition:

Physical and chemical properties: calcium fruit acid is white powder, calcium fruit acid is odorless and has no peculiar smell, calcium fruit acid has high solubility, calcium fruit acid has a good fruity taste

High solubility

Comparing the solubility of calcium citrate malate with similar products, the results are shown in the table. And its solubility was measured under the conditions of different pH values and different temperatures:

Products

Calcium Citrate Calcium Malate Calcium Citrate Calcium Malate Calcium Carbonate

CCM

Calcium content/% 21.08 23.28 21.91 40.00 23.57

Calcium dissolution/% 12.64 48.97 44.80 0.98 80.19

The results show that the calcium content of calcium citrate malate in similar products is moderate, and the solubility is obviously better than other products. Its solubility increases with the decrease of pH value, and it still has the ability in slightly alkaline and near neutral environment. Better solubility, the high solubility of calcium citrate malate in a wide pH range is an important feature related to high absorption. Temperature has little effect on its solubility, and the solubility is slightly higher at room temperature. Therefore, calcium citrate malate is more suitable as a calcium nutrition enhancer. At present, the absorption mechanism of calcium has not been fully understood, but it is generally believed that dissolution is a prerequisite for absorption.

2) High biological absorption and utilization

The biggest feature of calcium citrate malate is that the calcium ingested by the body has a high absorption rate. In addition, calcium citrate malate also has high biological availability such as promoting bone formation and alleviating bone loss. The high absorption of calcium citrate malate has been confirmed by animal experiments and clinical trials. Kobayashi and Koye used small intestinal ligation experiments on rats to study the balance of calcium absorption. The results showed that the retention rate of calcium from calcium citrate malate was 20.2% for calcium carbonate. Shows the high absorbency of calcium citrate malate. In addition, 10 women aged between 21 and 31 were used as subjects to compare the absorption rates of calcium citrate malate and calcium carbonate using the dual isotope method. The results showed that the calcium absorption rate from calcium citrate malate was 37.3%, which was significantly higher than that of calcium carbonate (29.6%). A clinical trial on the calcium absorption rate of calcium carbonate and calcium citrate malate was carried out on 12 adolescents aged 0-17. The results also proved that calcium citrate malate has high calcium absorption.

3) Reduce iron absorption barrier

Calcium usually hinders the absorption of other minerals. But calcium citrate malate can reduce the hindrance of iron absorption. 19 women aged 52-72 years were taken as subjects to study the effect of calcium on iron absorption.

4) Good flavor

Calcium usually gives people bad flavors such as "rough and spicy", but calcium citrate malate has the characteristics of fineness, softness and good flavor.

5) Safe and non-toxic

Calcium citrate malate is a general food raw material calcium with high safety. It belongs to GRAS in the United States and can be used in various foods. Acute toxicity in mice and 9-pressure feeding experiments in rats have been carried out, and the experimental results prove that calcium citrate malate is non-toxic.

The above characteristics of calcium citrate malate indicate that calcium citrate malate is a good calcium nutrient fortifier.

Application field: Calcium citrate malate has two main uses: the solid dosage form is used as a calcium supplement, made into pure tablets or added to bread, biscuits, pastries, candies, milk powder, breakfast foods and flavored snacks. Sexual food; liquid formulation is used for calcium-fortified beverages, and can be added to beverages such as milk and soy milk beverages. Beverages using calcium citrate malate as a calcium fortifier have been sold in many regions of the world. Sales have already begun in the United States (1986), Japan, and Europe. The Ministry of Health and Welfare of Japan has approved calcium citrate malate as a raw material for "special health food", and the Canadian government has approved calcium citrate malate swallow tablets and chewable tablets as medical calcium supplements. Calcium acid has not been widely developed and utilized.